Methylsulfonylmethane (MSM) is an organosulfur compound that is used topically for its potential anti-inflammatory, skin-hydrating, and wound-healing properties. It is commonly found in creams, lotion...
Methylsulfonylmethane (MSM) is an organosulfur compound that is used topically for its potential anti-inflammatory, skin-hydrating, and wound-healing properties. It is commonly found in creams, lotions, and gels. While generally considered safe for topical application, some individuals may experience mild skin irritation. Further research is needed to fully understand the benefits and optimal use of topical MSM.
Key Information
Outside Body Harmful Score
Common Dosage
Dosage varies greatly depending on the product and individual needs. Creams and lotions typically range from 1-10% MSM concentration. Follow product instructions.
Source Type
synthetic
Production Process
MSM is typically produced through a chemical reaction involving dimethyl sulfoxide (DMSO) and hydrogen peroxide. The DMSO is oxidized to form MSM, which is then purified through crystallization.
Use Type
Outside BodyPotential Benefits
Skin hydration is essential for maintaining skin elasticity, barrier function, and overall appearance. It reduces fine lines, protects against environmental stressors, and improves skin smoothness and suppleness.
Accelerates and supports the body's natural wound repair processes. This includes reducing inflammation, promoting collagen synthesis, increasing cell proliferation, and facilitating angiogenesis, leading to faster wound closure, reduced scarring, and decreased infection risk.
Reduces inflammation by inhibiting inflammatory pathways and the production of inflammatory molecules, thereby alleviating symptoms and protecting against tissue damage. This benefit helps modulate inflammatory responses and promote resolution.
MSM may reduce scar tissue formation by promoting collagen remodeling and reducing inflammation at the wound site. This could lead to thinner, more flexible scars.
Possible Side Effects
Skin irritation involves symptoms like redness, itching, and rashes due to contact with irritants, allergens, or environmental factors. Severity varies based on the cause, individual sensitivity, and affected area; persistent cases may lead to secondary infections.
Allergic reactions are adverse immune responses to normally harmless substances, ranging from mild skin irritation to severe anaphylaxis. Symptoms can include skin issues, swelling, breathing difficulties, and anaphylaxis requires immediate epinephrine injection.
Scientific Evidence
Kogan, G. A., et al. "The effect of methylsulfonylmethane on the skin." International journal of cosmetic science 39.6 (2017): 585-591.; Butawan, M., Benjamin, R. L., Bloomer, R. J. (2017). Methylsulfonylmethane: Applications and Safety Evaluation. Nutrients, 9(3), 290.
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