About Iron

Iron is an essential trace mineral primarily involved in oxygen transport and storage as a component of hemoglobin in red blood cells and myoglobin in muscle. It is also a cofactor for numerous enzymes involved in energy metabolism, DNA synthesis, and cellular respiration. Iron exists in two primary dietary forms: heme iron (from animal sources, highly bioavailable) and non-heme iron (from plant sources and supplements, with bioavailability influenced by other dietary components). Deficiency leads to anemia, while excess can cause toxicity, making balanced intake critical.

Official resources

Fact sheets from the NIH Office of Dietary Supplements related to this ingredient group.

Dietary Supplement Label Database

Ingredient group data in NutriNav is aligned with the NIH Dietary Supplement Label Database (DSLD).

DSLD group id
7473

At a glance

Suggested daily

RDA varies by age, sex, and life stage. For adult men and postmenopausal women: 8 mg/day. For premenopausal women: 18 mg/day. During pregnancy: 27 mg/day.

Max safe daily

UL for adults is 45 mg/day of elemental iron from supplements and fortified foods.

Approval status

supplement

Compare All Forms

15 forms

Compare supplement forms of Iron by absorption quality and what your body actually gets from each:

High Moderate Low
Form Absorption Steps to absorb Notes Action
Ferrous Bisglycinate (Iron Bisglycinate)

Highly bioavailable, gentle-on-the-stomach iron supplement.

  • UNII: J7A7A9K0X0
  • CAS: 20150-34-9
  • Label category: synthetic
β€” β€” β€” View β†’
Ferrous Fumarate

Iron supplement for anemia prevention and treatment

  • UNII: R5L488RY0Q
  • CAS: 141-01-5
  • Label category: synthetic
β€” β€” β€” View β†’
Ferrous Sulfate

Common iron supplement for anemia. May cause stomach upset;...

  • UNII: 39R4TAN1VT
  • CAS: 7720-78-7 (anhydrous); 7782-63-0 (heptahydrate)
  • Label category: synthetic
β€” β€” β€” View β†’
Heme Iron Polypeptide β€” β€” β€” View β†’
Heme Iron Polypeptide (HIP)

Gentle, high-absorption iron with minimal GI upset. Often de...

  • CAS: 9012-76-4 (related for protein hydrolysate-iron complexes)
  • Label category: hybrid
β€” β€” β€” View β†’
Iron alpha-ketoglutarate β€” β€” β€” View β†’
Iron Amino Acid Chelate

Highly bioavailable, gentle iron form.

  • CAS: Varies by specific chelate (e.g., Iron Bisglycinate: 20150-34-9)
  • Label category: synthetic
β€” β€” β€” View β†’
Iron ascorbate β€” β€” β€” View β†’
Iron Bile salt β€” β€” β€” View β†’
Iron Bile salt (unspecified)
  • DSLD group id: 7476
β€” β€” β€” View β†’
Iron Fructo-Oligosaccharides β€” β€” β€” View β†’
Iron oxide β€” β€” β€” View β†’
Iron picolinate β€” β€” β€” View β†’
Iron pyrite β€” β€” β€” View β†’
Polysaccharide-Iron Complex

Iron supplement with improved gastrointestinal tolerance.

  • UNII: U5VDB62G2S
  • CAS: 9007-73-2
  • Label category: synthetic
β€” β€” β€” View β†’

Also appears on labels as

Additional names seen on supplement labels for forms of this ingredient (beyond the main aliases above).

Amino Acid Chelated Iron, Copperas, Feostat, Ferric iron polypeptide, Ferric polymaltose, Ferrospan, Ferrous sulphate, Fersamal, Green vitriol, IPC, Iron-polysaccharide complex, Iron fumarate, Iron Glycinate Chelate (specific type), Iron polymaltose, Iron polypeptide complex, Iron sulfate, Iron vitriol, Palafer

Type: Minerals

Inorganic elements essential for various physiological functions including bone formation, nerve function, and enzyme activity.

Absorption: Minerals often compete for absorption. Chelated forms generally have better bioavailability.

Interactions: High doses of some minerals can interfere with absorption of others. Some minerals can interact with medications.

Watch out for

Possible interactions or cautions β€” talk to a healthcare provider if unsure.

  • Calcium may inhibit iron absorption.
  • Vitamin C enhances iron absorption.

Potential Benefits

Benefits associated with Iron forms:

And 16 more benefits...

Potential Side Effects

Side effects associated with Iron forms:

And 9 more side effects...

What does the research say?

Heme Iron Polypeptide has been studied for its efficacy in treating iron deficiency anemia, particularly in pregnant women and children. Research indicates that it is better tolerated and more effective than traditional iron supplements like ferrous sulfate.