Fisetin is a flavonol with potential senolytic, antioxidant, and anti-inflammatory properties, benefiting healthy aging and cognitive function.
Fisetin is a naturally occurring flavonol found in various fruits and vegetables, possessing senolytic, antioxidant, anti-inflammatory, and neuroprotective properties. It is available as a dietary supplement and is being researched for its potential to promote healthy aging, improve cognitive function, and increase healthspan. While generally considered safe, potential side effects include mild gastrointestinal discomfort, and interactions with certain medications are possible. Consult with a healthcare professional before use, especially if you have existing health conditions or are taking medications.
Key Information
Inside Body Harmful Score
Common Dosage
100-500mg daily
Source Type
natural
Production Process
Primarily extracted from various fruits and vegetables (e.g., strawberries, apples, onions) or synthesized chemically for larger-scale supplement production.
Use Type
Inside BodyPotential Benefits
This benefit reduces inflammation by modulating inflammatory pathways and inhibiting pro-inflammatory cytokines, resulting in reduced pain, swelling, and improved function. It is beneficial for conditions like arthritis, inflammatory bowel disease, cardiovascular disease, and skin conditions.
Antioxidants neutralize harmful free radicals, preventing cellular damage and reducing oxidative stress, which can contribute to overall health and disease prevention. They work by donating electrons to stabilize free radicals and supporting antioxidant enzyme systems.
Caffeine improves cognitive function by blocking adenosine receptors, increasing neuronal activity and enhancing alertness, attention, and memory. This results in faster reaction times and better sustained focus.
Neuroprotective effects safeguard brain cells from damage, potentially improving cognitive function and preventing neurodegenerative diseases. This is achieved through antioxidant, anti-inflammatory, and neuronal survival support mechanisms.
Aged garlic extract acts as an antioxidant by neutralizing free radicals, protecting cells from damage and potentially reducing the risk of chronic diseases. The allicin-derived metabolites are the active components.
Reishi mushrooms contain triterpenes that may reduce inflammation by modulating inflammatory pathways. This could benefit conditions associated with chronic inflammation.
Fisetin selectively eliminates senescent cells by inducing apoptosis, potentially improving healthspan and reducing age-related pathologies. This senolytic effect helps to remove dysfunctional cells that contribute to aging and disease.
Possible Side Effects
Drug interactions can alter a drug's effectiveness, leading to either increased risk of blood clots or bleeding, particularly with anticoagulants. Monitoring is essential to manage these interactions.
Gastrointestinal discomfort includes nausea, bloating, and diarrhea, typically mild and transient. Symptoms are often dose-dependent and vary in severity.
High doses of MK-7 may cause mild gastrointestinal discomfort such as nausea or upset stomach. Symptoms are typically mild and transient.
Scientific Evidence
Key scientific sources and studies include research on senolytic activity in vitro and in vivo, antioxidant mechanisms, effects on neuronal survival and cognitive function in animal models, and preliminary human studies on safety and efficacy for healthy aging. Specific journal publications include but are not limited to Aging, The Journals of Gerontology, and Antioxidants.
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