Epigallocatechin gallate (EGCG), from green tea, is an antioxidant and polyphenol offering cardiovascular and weight management benefits.
Epigallocatechin gallate (EGCG) is a polyphenol antioxidant predominantly found in green tea extracts. It is available as a dietary supplement and is studied for its potential benefits, including cardiovascular health, weight management, neuroprotection, antioxidant, and anti-inflammatory properties. While generally considered safe at moderate doses, high doses of EGCG can lead to gastrointestinal distress and, in rare instances, liver problems. It may also interfere with iron absorption and interact with certain medications. Individuals considering EGCG supplementation should consult with a healthcare professional, particularly those with pre-existing health conditions or those taking medications.
Key Information
Inside Body Harmful Score
Common Dosage
150-800mg daily
Source Type
natural
Production Process
Extracted from green tea leaves using various solvent extraction methods, followed by purification and concentration to isolate EGCG.
Use Type
Inside BodyPotential Benefits
Cardiovascular health ensures efficient blood circulation by maintaining healthy heart and blood vessels. Benefits include reduced risk of heart disease and stroke through improved blood flow and heart function.
Antioxidant protection defends the body against free radical damage, reducing the risk of chronic diseases and promoting overall cellular health. This is achieved by neutralizing unstable molecules that cause oxidative stress and cellular damage.
Neuroprotection aims to protect the brain and nervous system from damage and degeneration by preventing neuronal cell death, reducing inflammation, and enhancing synaptic plasticity. Strategies include lifestyle modifications, nutritional supplementation, and pharmacological interventions to mitigate effects of aging, neurodegenerative diseases, stroke, and traumatic brain injury.
This benefit reduces inflammation by modulating inflammatory pathways and inhibiting pro-inflammatory cytokines, resulting in reduced pain, swelling, and improved function. It is beneficial for conditions like arthritis, inflammatory bowel disease, cardiovascular disease, and skin conditions.
Antioxidants protect cells from damage caused by free radicals, reducing inflammation, and promoting overall health. They neutralize these unstable molecules by donating electrons and preventing them from damaging cellular structures.
Psyllium husk promotes satiety by absorbing water in the gut, potentially reducing calorie intake and aiding weight management. It increases stool bulk, contributing to a feeling of fullness.
Reishi mushrooms contain triterpenes that may reduce inflammation by modulating inflammatory pathways. This could benefit conditions associated with chronic inflammation.
Possible Side Effects
Gastrointestinal upset involves a variety of digestive symptoms like nausea, diarrhea, and abdominal pain. It can range from mild discomfort to severe pain and may indicate an underlying condition if persistent.
Headache is pain in the head ranging from mild to severe, potentially with nausea, light/sound sensitivity, or dizziness. It can be caused by tension, dehydration, stress, or medication side effects, and persistent headaches require medical evaluation.
Liver toxicity (hepatotoxicity) is liver damage induced by substances such as drugs or chemicals, potentially leading to liver failure. Symptoms include jaundice, abdominal pain, and fatigue, with severe cases possibly fatal.
Gastrointestinal issues include nausea, diarrhea, abdominal discomfort, and vomiting, potentially stemming from altered gut motility, microbiota changes, or irritation. While often mild, persistent symptoms necessitate evaluation, and contributing factors like pre-existing conditions should be considered.
Drug interactions can alter a drug's effectiveness, leading to either increased risk of blood clots or bleeding, particularly with anticoagulants. Monitoring is essential to manage these interactions.
Iron absorption interference inhibits the body's ability to absorb iron, potentially leading to iron deficiency and related symptoms such as fatigue and weakness. This occurs when substances bind to iron, preventing its absorption in the small intestine.
High doses of green tea extract, especially in concentrated forms, can rarely cause liver toxicity. Individuals with pre-existing liver conditions should exercise caution.
Liver problems, including potential liver damage, are a rare but serious side effect. Symptoms can include jaundice, abdominal pain, and fatigue, potentially leading to liver failure.
Scientific Evidence
Studies published in journals such as the *Journal of the American College of Nutrition*, *The American Journal of Clinical Nutrition*, and *Molecular Nutrition & Food Research* have investigated the effects of EGCG on various health outcomes. Specific clinical trials and meta-analyses provide evidence for the effects mentioned. Further research is ongoing to fully elucidate EGCG's mechanisms and long-term effects.
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