Collagen Type II supports joint health and may reduce pain/stiffness associated with osteoarthritis and rheumatoid arthritis.
Collagen Type II is a naturally occurring protein primarily sourced from chicken or bovine cartilage, and used as a dietary supplement to support joint health. Undenatured collagen type II (UC-II) is a specific form believed to work through oral tolerization to reduce joint inflammation and pain. While generally considered safe, mild gastrointestinal side effects and rare allergic reactions are possible. The typical dosage for UC-II is 40mg daily. Evidence supporting its benefits for joint pain reduction and improved flexibility is moderate.
Key Information
Inside Body Harmful Score
Common Dosage
40mg daily (for undenatured collagen type II - UC-II)
Source Type
natural
Production Process
Typically extracted from the sternum cartilage of chickens, although other sources like bovine cartilage exist. The extraction process involves enzymatic digestion or other methods to isolate and purify the collagen type II.
Use Type
Inside BodyPotential Benefits
Joint Health enhances joint function by supporting cartilage and reducing inflammation. It alleviates pain and stiffness associated with conditions like osteoarthritis.
Undenatured collagen type II may alleviate osteoarthritis symptoms by reducing inflammation and pain in joints. It potentially works by modulating the immune response in the gut.
Undenatured collagen type II may alleviate rheumatoid arthritis symptoms by promoting immune tolerance to joint collagen. This can potentially reduce inflammation and pain in affected joints.
Possible Side Effects
Allergic reactions are hypersensitivity responses to allergens, ranging from mild skin irritation to life-threatening anaphylaxis. Symptoms vary widely and are caused by an immune response.
Mild gastrointestinal discomfort involves low severity nausea, stomach upset, or diarrhea. Symptoms are typically transient and self-limiting.
Scientific Evidence
Key studies include randomized controlled trials evaluating the efficacy of UC-II in reducing pain and improving function in individuals with osteoarthritis. Research often focuses on the oral tolerization mechanism of action and its effects on the immune system's response to cartilage.
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