Citicoline supports brain health by increasing key neurotransmitters, potentially enhancing cognitive function and memory.
Citicoline (CDP-Choline) is a naturally occurring compound vital for brain health. It functions by elevating levels of key neurotransmitters like acetylcholine, fortifying neural structures, and providing neuroprotective effects. As a nootropic supplement, citicoline is used to boost cognitive abilities, enhance memory, and aid in stroke recovery. While generally well-tolerated, some users might encounter minor side effects like headaches, insomnia, or gastrointestinal disturbances. Research suggests benefits related to cognitive enhancement, memory, stroke recovery, and neuroprotection.
Key Information
Inside Body Harmful Score
Common Dosage
250-2000mg daily
Source Type
natural
Production Process
Citicoline is produced through enzymatic synthesis, typically involving the transfer of cytidine diphosphate to choline.
Use Type
Inside BodyPotential Benefits
Cognitive enhancement improves mental performance by boosting memory, attention, and processing speed. It works by promoting neuronal health and protecting against cognitive decline.
Neuroprotection aims to protect the brain and nervous system from damage and degeneration by preventing neuronal cell death, reducing inflammation, and enhancing synaptic plasticity. Strategies include lifestyle modifications, nutritional supplementation, and pharmacological interventions to mitigate effects of aging, neurodegenerative diseases, stroke, and traumatic brain injury.
Alpha-GPC may improve stroke recovery by increasing acetylcholine levels, enhancing neuronal plasticity, and aiding in the repair of damaged neuronal structures. It potentially facilitates the brain's ability to reorganize and form new connections after a stroke.
Citicoline may enhance memory and cognitive function in individuals with age-related cognitive decline and early Alzheimer's by supporting neurotransmitter levels and neuronal health. It potentially improves brain function in affected individuals.
Citicoline protects brain cells by supporting neuronal membrane repair, enhancing cholinergic neurotransmission, and reducing oxidative stress and excitotoxicity. This helps to maintain and improve overall neuronal health.
Possible Side Effects
Insomnia is a sleep disorder involving difficulty falling or staying asleep, leading to non-restorative sleep. It can be triggered by various factors and can result in daytime fatigue and impaired cognitive function.
Headache is pain in the head ranging from mild to severe, potentially with nausea, light/sound sensitivity, or dizziness. It can be caused by tension, dehydration, stress, or medication side effects, and persistent headaches require medical evaluation.
Anxiety as a side effect involves feelings of worry and unease, potentially leading to restlessness, difficulty concentrating, and panic attacks. It can be triggered by various mechanisms, including drug effects on the CNS or hormonal imbalances, and is often exacerbated by pre-existing anxiety disorders.
Gastrointestinal issues include nausea, diarrhea, abdominal discomfort, and vomiting, potentially stemming from altered gut motility, microbiota changes, or irritation. While often mild, persistent symptoms necessitate evaluation, and contributing factors like pre-existing conditions should be considered.
Scientific Evidence
Several randomized controlled trials and meta-analyses support the efficacy of citicoline for cognitive enhancement, stroke recovery, and neuroprotection. Key studies have been published in journals such as Stroke, Journal of Neurology, Neurosurgery & Psychiatry, and Advances in Therapy. Specific study details can be found through PubMed and other scientific databases by searching for 'citicoline' and relevant keywords.
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