Centella Asiatica extract (madecassoside) promotes wound healing and skin rejuvenation by boosting collagen and reducing inflammation.
Centella Asiatica extract, specifically madecassoside, is a natural compound derived from the Centella Asiatica plant. It is widely recognized for its wound-healing, anti-inflammatory, and skin-rejuvenating properties. Madecassoside promotes collagen synthesis, enhances skin hydration, and reduces inflammation, making it a valuable ingredient in cosmetic and dermatological formulations. While generally safe, some individuals may experience mild skin irritation or allergic reactions. The typical dosage range is 30-90mg daily of a standardized extract containing 40% madecassoside.
Key Information
Outside Body Harmful Score
Common Dosage
30-90mg daily of standardized extract containing 40% madecassoside
Source Type
natural
Production Process
Centella Asiatica extract, particularly madecassoside, is derived from the Centella Asiatica plant. The plant material is typically extracted using solvents such as ethanol or water, followed by purification and isolation of madecassoside. Different extraction methods and purification processes may influence the final concentration and purity of madecassoside.
Use Type
Outside BodyPotential Benefits
Skin hydration is essential for maintaining skin elasticity, barrier function, and overall appearance. It reduces fine lines, protects against environmental stressors, and improves skin smoothness and suppleness.
Accelerates and supports the body's natural wound repair processes. This includes reducing inflammation, promoting collagen synthesis, increasing cell proliferation, and facilitating angiogenesis, leading to faster wound closure, reduced scarring, and decreased infection risk.
This benefit reduces inflammation by modulating inflammatory pathways and inhibiting pro-inflammatory cytokines, resulting in reduced pain, swelling, and improved function. It is beneficial for conditions like arthritis, inflammatory bowel disease, cardiovascular disease, and skin conditions.
Bakuchiol stimulates collagen production, improving skin elasticity and reducing the appearance of fine lines and wrinkles. It enhances skin tone and texture for a more youthful appearance.
Rosehip oil may reduce the appearance of scars, including surgical and acne scars, by promoting skin regeneration and reducing inflammation and discoloration. Its fatty acids and antioxidants aid in the healing process and improve skin texture.
Possible Side Effects
Skin irritation involves symptoms like redness, itching, and rashes due to contact with irritants, allergens, or environmental factors. Severity varies based on the cause, individual sensitivity, and affected area; persistent cases may lead to secondary infections.
Allergic reactions are hypersensitivity responses to allergens, ranging from mild skin irritation to life-threatening anaphylaxis. Symptoms vary widely and are caused by an immune response.
Photosensitivity is an increased sensitivity to UV radiation, leading to sunburn, rash, or blistering. Reactions can be phototoxic or photoallergic, with symptoms ranging from mild redness to severe blistering and potentially increasing skin cancer risk with prolonged exposure.
Scientific Evidence
Bylka W, Znajdek-Awiżeń P, Goscianska J, et al. Centella asiatica in cosmetology. Postepy Dermatol Alergol. 2013;30(1):46-49. doi:10.5114/pdia.2013.33378; Goh CL, Contact Dermatitis. Aetiology and relevant allergens in Singapore. Contact Dermatitis. 2002;46(1):3-9; Lu L, Kong M, Xu Y, et al. Asiaticoside induction for cell-cycle progression, proliferation and collagen synthesis in human dermal fibroblasts. Int J Dermatol. 2004;43(11):801-807.
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