SAMe

S-Adenosylmethionine (SAMe) is a naturally occurring compound involved in numerous biochemical processes, including methylation, transsulfuration, and aminopropylation. As a supplement, SAMe is primarily used for osteoarthritis pain relief, depression management, and liver health support. While generally considered safe for most, it can cause gastrointestinal side effects, anxiety, and insomnia. It is contraindicated or requires careful monitoring in individuals with bipolar disorder due to the risk of inducing mania or hypomania. SAMe can interact with certain medications, particularly antidepressants, and should be used under the guidance of a healthcare professional.

Clinical trials and meta-analyses have investigated the efficacy of SAMe for osteoarthritis, depression, and liver disease. Key research areas include its impact on cartilage metabolism, neurotransmitter synthesis, and liver detoxification pathways. References to relevant scientific literature (e.g., PubMed indexed studies) should be consulted for specific evidence.