Alpha-lipoic acid (ALA) is a naturally occurring and synthetically produced antioxidant compound crucial for energy production within cells. It acts as a potent antioxidant, regenerating other antioxi...
Alpha-lipoic acid (ALA) is a naturally occurring and synthetically produced antioxidant compound crucial for energy production within cells. It acts as a potent antioxidant, regenerating other antioxidants and protecting against oxidative stress. ALA is commonly supplemented for its potential benefits in managing diabetes, alleviating neuropathic pain, and supporting cognitive function. While generally safe, ALA can cause gastrointestinal side effects and may interact with medications that affect blood sugar levels. Individuals should consult with a healthcare professional before taking ALA supplements, especially those with pre-existing medical conditions or those taking medications.
Key Information
Inside Body Harmful Score
Common Dosage
100-600mg daily
Source Type
natural
Production Process
ALA is synthesized naturally in the body from octanoic acid and cysteine. It can also be produced synthetically for use in supplements.
Use Type
Inside BodyPotential Benefits
Enhances mental processes involved in thinking, learning, and remembering, including memory, attention, focus, and processing speed. Benefits range from improved mental clarity to significant enhancements in cognitive abilities, especially in those with cognitive decline.
Antioxidant support protects cells from damage by neutralizing free radicals, supporting immune function, and reducing inflammation. It contributes to overall health and may reduce the risk of chronic diseases.
Supports healthy nerve function in both the central and peripheral nervous systems. This includes nerve signal transmission, nerve cell protection, and nerve regeneration.
Blood sugar control maintains blood glucose levels within a healthy range, preventing hyperglycemia and hypoglycemia. This involves insulin regulation, glucose uptake, and liver glucose production, crucial for preventing conditions like type 2 diabetes.
Magnesium regulates blood sugar by improving insulin sensitivity and glucose metabolism. Supplementation can improve glycemic control, especially in those with deficiencies or insulin resistance.
Possible Side Effects
A rash is a skin eruption with various appearances, causes, and associated symptoms like itching and pain. It can be triggered by allergies, infections, or underlying medical conditions and can be acute or chronic.
A mild, typically non-itchy skin rash, characterized by small bumps or red patches, can occur in some individuals, especially with high doses. It usually resolves spontaneously within a few days to weeks.
Gastrointestinal issues include nausea, diarrhea, abdominal discomfort, and vomiting, potentially stemming from altered gut motility, microbiota changes, or irritation. While often mild, persistent symptoms necessitate evaluation, and contributing factors like pre-existing conditions should be considered.
Hypoglycemia is a condition of low blood sugar, potentially caused by alpha-lipoic acid (ALA) enhancing the effects of blood sugar-lowering medications. It can cause symptoms ranging from shakiness to severe neurological issues.
Scientific Evidence
Numerous studies published in journals such as Diabetes Care, Archives of Biochemistry and Biophysics, and the Journal of Alzheimer's Disease support the use of ALA for its antioxidant, anti-diabetic, and neuroprotective effects. Meta-analyses and systematic reviews provide comprehensive evaluations of the available evidence. Trials investigating the efficacy and safety of ALA in diabetic neuropathy are particularly well-documented.
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